An Agent-based Model Approach to Multi-phase Life-cycle for Contact Inhibited, Anchorage Dependent Cells

Authored by Ross. D. Hoehn, Ashley. M. Schreder, Mohammed Fayez Al Rez, Sabre Kais

Date Published: 2014-12

DOI: 10.1007/s12539-012-0236-4

Sponsors: National Plan for Science and Technology)

Platforms: No platforms listed

Model Documentation: Other Narrative Flow charts Mathematical description

Model Code URLs: Model code not found

Abstract

Cellular agent-based models are a technique that can be easily adapted to describe nuances of a particular cell type. Within we have concentrated on the cellular particularities of the human Endothelial Cell, explicitly the effects both of anchorage dependency and of heightened scaffold binding on the total confluence time of a system. By expansion of a discrete, homogeneous, asynchronous cellular model to account for several states per cell (phases within a cell's life); we accommodate and track dependencies of confluence time and population dynamics on these factors. Increasing the total motility time, analogous to weakening the binding between lattice and cell, affects the system in unique ways from increasing the average cellular velocity; each degree of freedom allows for control over the time length the system achieves logistic growth and confluence. These additional factors may allow for greater control over behaviors of the system. Examinations of system's dependence on both seed state velocity and binding are also enclosed.

Tags

Cellular regeneration Discrete automaton model