Individual based modeling of Pseudomonas aeruginosa biofilm with three detachment mechanisms

Authored by Cheng Li, Yilei Zhang, Cohen Yehuda

Date Published: 2015

DOI: 10.1039/c5ra11041f

Sponsors: Singapore Ministry of Education

Platforms: No platforms listed

Model Documentation: Other Narrative Mathematical description

Model Code URLs: Model code not found

Abstract

Individual based simulation approach has attracted more and more interest in biofilm simulation. Different from the conventional biomass based simulation method, detachments are not available in many individual based simulation packages. In this paper, three detachment mechanisms were successfully integrated into an individual-based modeling package (iDynoMiCs). With the new capabilities, the influence of bacterial detachment on Pseudomonas aeruginosa biofilm was studied. The simulated results agreed well with previous reports, including the effect of shear detachment on smoothening biofilms, nutrient-limited detachment on hollowing the biofilms, and erosion detachment on isolating bacterial clusters. New findings were also discovered including the effects of different detachment mechanisms on the equilibrium state, time-dependent effects of each detachment mechanism on biofilm structure, sensitivity of the detachment coefficient values, etc.

Tags

growth Waste-water treatment Flow Starvation-induced dispersion Cellular-automaton approach Substrate loading rate Putida biofilms Shear-stress