Investigation of mechanism of bone regeneration in a porous biodegradable calcium phosphate (CaP) scaffold by a combination of a multi-scale agent-based model and experimental optimization/validation

Authored by Le Zhang, Xiaobo Zhou, Hua Tan, Bin Hu, Minna Qiao, Hongjie Gao, Chang Ming Li

Date Published: 2016

DOI: 10.1039/c6nr01637e

Sponsors: Chinese National Natural Science Foundation Fundamental Research Funds for the Central Universities of China United States National Institutes of Health (NIH) Chongqing excellent youth award Chinese Recruitment Program of Global Youth Experts Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies

Platforms: No platforms listed

Model Documentation: Other Narrative Flow charts Mathematical description

Model Code URLs: Model code not found

Abstract

Herein, we have developed a novel approach to investigate the mechanism of bone regeneration in a porous biodegradable calcium phosphate (CaP) scaffold by a combination of a multi-scale agent-based model, experimental optimization of key parameters and experimental data validation of the predictive power of the model. The advantages of this study are that the impact of mechanical stimulation on bone regeneration in a porous biodegradable CaP scaffold is considered, experimental design is used to investigate the optimal combination of growth factors loaded on the porous biodegradable CaP scaffold to promote bone regeneration and the training, testing and analysis of the model are carried out by using experimental data, a data-mining algorithm and related sensitivity analysis. The results reveal that mechanical stimulation has a great impact on bone regeneration in a porous biodegradable CaP scaffold and the optimal combination of growth factors that are encapsulated in nanospheres and loaded into porous biodegradable CaP scaffolds layer-by-layer can effectively promote bone regeneration. Furthermore, the model is robust and able to predict the development of bone regeneration under specified conditions.

Tags

Angiogenesis systems Tissue differentiation