Toxicokinetic-toxicodynamic modelling in an individual based context-Consequences of parameter variability

Authored by Roman Ashauer

Date Published: 2010

DOI: 10.1016/j.ecolmodel.2010.01.015

Sponsors: Swiss National Science Foundation (SNSF)

Platforms: swiss national science foundation

Model Documentation: Other Narrative Mathematical description

Model Code URLs: Model code not found

Abstract

Toxicokinetic-toxicodynamic (TKTD) models simulate the time-course of toxicant concentration in the organism and toxicity at the level of the organism. A link between TKTD models that simulate survival and individual based models for populations (IBMs) is proposed which allows TKTD parameters to vary between individuals. The TKTD-IBM predicts different survival in response to toxicants when TKTD parameters vary amongst individuals compared to the survival predicted with fixed TKTD parameters. The model with fixed parameters represents the concept of stochastic death whereas the model with variable parameters behaves, at least partly, according to the individual tolerance distribution concept. The whole set of TKTD parameters of an individual can be interpreted as constituting ``individual tolerance{''}. (C) 2010 Elsevier B.V. All rights reserved.

Tags

Dynamics Pesticides exposure Invertebrates