A multiscale computational framework to understand vascular adaptation

Authored by M Garbey, M Rahman, S Berceli

Date Published: 2015

DOI: 10.1016/j.jocs.2015.02.002

Sponsors: No sponsors listed

Platforms: Java C MATLAB

Model Documentation: UML Other Narrative Mathematical description

Model Code URLs: Model code not found

Abstract

The failure rate for vascular interventions (vein bypass grafting, arterial angioplasty/stenting) remains unacceptably high. Over the past two decades, researchers have applied a wide variety of approaches to investigate the primary failure mechanisms, neointimal hyperplasia and aberrant remodeling of the wall, in an effort to identify novel therapeutic strategies. Despite incremental progress, specific cause/effect linkages among the primary drivers of the pathology, (hemodynamic factors, inflammatory biochemical mediators, cellular effectors) and vascular occlusive phenotype remain lacking. We propose a multiscale computational framework of vascular adaptation to develop a bridge between theory and experimental observation and to provide a method for the systematic testing of relevant clinical hypotheses. Cornerstone to our model is a feedback mechanism between environmental conditions and dynamic tissue plasticity described at the cellular level with an agent based model. Our implementation (i) is modular, (ii) starts from basic mechano-biology principle at the cell level and (iii) facilitates the agile development of the model. (C) 2015 The Authors. Published by Elsevier B.V.

Tags

Simulation Dynamics Model apoptosis Vein grafts Flow Arterial Pressure Wall