Agent-Based Modeling Reveals Possible Mechanisms for Observed Aggregation Cell Behaviors

Authored by Zhaoyang Zhang, Oleg A Igoshin, Christopher R Cotter, Lawrence J Shimkets

Date Published: 2018

DOI: 10.1016/j.bpj.2018.11.005

Sponsors: United States National Science Foundation (NSF)

Platforms: C++

Model Documentation: Other Narrative Mathematical description

Model Code URLs: https://github.com/zzyustcrice/chemotaxis2

Abstract

Myxococcus xanthus is a soil bacterium that serves as a model system for biological self-organization. Cells form distinct, dynamic patterns depending on environmental conditions. An agent-based model was used to understand how M. xanthus cells aggregate into multicellular mounds in response to starvation. In this model, each cell is modeled as an agent represented by a point particle and characterized by its position and moving direction. At low agent density, the model recapitulates the dynamic patterns observed by experiments and a previous biophysical model. To study aggregation at high cell density, we extended the model based on the recent experimental observation that cells exhibit biased movement toward aggregates. We tested two possible mechanisms for this biased movement and demonstrate that a chemotaxis model with adaptation can reproduce the observed experimental results leading to the formation of stable aggregates. Furthermore, our model reproduces the experimentally observed patterns of cell alignment around aggregates.

Tags

chemotaxis Waves Pattern-formation Motility Myxobacteria Driven Myxococcus-xanthus Chemosensory pathways