A fully coupled framework for in silico investigation of in-stent restenosis
Authored by Shibo Li, Long Lei, Ying Hu, Yanfang Zhang, Shijia Zhao, Jianwei Zhang
Date Published: 2019
DOI: 10.1080/10255842.2018.1545017
Sponsors:
Chinese National Natural Science Foundation
Platforms:
MATLAB
Model Documentation:
Other Narrative
Pseudocode
Model Code URLs:
Model code not found
Abstract
Finite element analysis (FEA) can be implemented along with Agent-based
model (ABM) to investigate the biomechanical and mechanobiological
mechanisms of pathophysiological processes. However, traditional ABM-FEA
approaches are often partially coupled and lack the feedback responses
from biological analysis. To overcome this problem, a fully coupled
ABM-FEA framework is developed in this paper by linking the macro-scale
and cell-scale modules bi-directionally. Numerical studies of the
in-stent restenosis process are conducted using the proposed approach
and comparisons are made between the two types of frameworks. A
reduction in lumen loss rate, which is possibly caused by the
time-varying stresses, is observed in the fully coupled simulations. The
re-endothelialisation process is also simulated under different
frameworks and the simulation results show strong inhibition of
endothelial cells to vascular restenosis. The proposed method is proved
to be effective to explain the biomechanical-mechanobiological coupling
characteristics of the restenosis problem and can be utilized for stent
design and optimization.
Tags
Agent-based model
Migration
proliferation
in-stent restenosis
biomechanics
Mathematical-model
Smooth-muscle-cells
Finite element
Mechanobiology
Neointimal hyperplasia
Human coronary-arteries
Matrix-metalloproteinase