Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?
Authored by Pierre Degond, Giacomo Dimarco, Mathieu Leroy-Leretre, Martine Cazales, Marie-Laure Boizeau, Bernard Ducommun, Valerie Lobjois
Date Published: 2017
DOI: 10.1007/s11538-017-0333-y
Sponsors:
United Kingdom Engineering and Physical Sciences Research Council (EPSRC)
United States National Science Foundation (NSF)
Wolfson foundation
Platforms:
No platforms listed
Model Documentation:
Other Narrative
Mathematical description
Model Code URLs:
Model code not found
Abstract
This paper investigates cell proliferation dynamics in small tumor cell
aggregates using an individual-based model (IBM). The simulation model
is designed to study the morphology of the cell population and of the
cell lineages as well as the impact of the orientation of the division
plane on this morphology. Our IBM model is based on the hypothesis that
cells are incompressible objects that grow in size and divide once a
threshold size is reached, and that newly born cell adhere to the
existing cell cluster. We performed comparisons between the simulation
model and experimental data by using several statistical indicators. The
results suggest that the emergence of particular morphologies can be
explained by simple mechanical interactions.
Tags
Individual-based model
Migration
tissue architecture
cancer
Cell proliferation
growth
In-vitro
Mathematical-model
Adhesion
Colonic crypt
Monoclonal conversion
Mitotic spindle orientation
Energy minimization
Lineage
morphology