An investigation of damage mechanisms in mechanobiological models of in-stent restenosis
Authored by David R Nolan, Caitrioria Lally
Date Published: 2018
DOI: 10.1016/j.jocs.2017.04.009
Sponsors:
Science Foundation Ireland
Platforms:
MATLAB
Model Documentation:
Other Narrative
Flow charts
Mathematical description
Model Code URLs:
Model code not found
Abstract
The mechanisms behind in-stent restenosis, the re-narrowing of a stented
artery, are poorly understood. However it is known that mechanical
damage due to stent implantation plays a major role. This paper
investigates the mechanism behind damage-induced cell proliferation
using a coupled finite element and agent based model, assuming it is
based on a) instantaneous loading, or b) cyclic loading. Furthermore the
role of remnant endothelial cells in attenuating in-stent restenosis is
examined. Results show that a cyclic damage model predicts a
non-physiological, overly proliferative response, whilst the
instantaneous model demonstrates that lumen loss may be regulated by
re-endothelialisation. (C) 2017 Elsevier B.V. All rights reserved.
Tags
Agent based model
proliferation
restenosis
Strain
Metaanalysis
Tissue
Modulation
Smooth-muscle-cells
Finite element
Stent
Mechanobiology
Drug-eluting-stents
Self-expanding stents
Neointimal hyperplasia
Arterial injury