SIMULATION OF ASCORBIC ACID RELEASE FROM ALGINATE-WHEY PROTEIN CONCENTRATES MICROSPHERES AT THE SIMULATED GASTROINTESTINAL CONDITION USING NETLOGO PLATFORM

Authored by Mohsen Zandi

Date Published: 2017

DOI: 10.1111/jfpe.12327

Sponsors: No sponsors listed

Platforms: NetLogo

Model Documentation: Other Narrative

Model Code URLs: Model code not found

Abstract

In this article, our earlier researches were applied for ascorbic acid (AA) release study from Alginate-Whey Protein Concentrate (AL-WPC-AA) microcapsule at the simulated gastrointestinal media. So, we created an agent-based simulator using NetLogo platform to develop the virtual release tools. Diffusion equation is then fitted to the experimental release data, and finally diffusion coefficient and permeability funded for each condition. Results indicated that this agent-based model can simulate the AA release process well, and there is a good R-2 values (above 88.3\%) between experimental and model release data. Conversely, results also show that the presence of the shear force and enzymes (pepsin and pancreatin) at the simulated gastrointestinal conditions significantly increase diffusion coefficients and release rate. Finally, this research suggested that we can easily use this agent-based model for various nutrients and different situations.

Tags

Vehicles Colloidosomes Profiles Drug-delivery Vitamin-c