Agent-based model of macrophage action on endocrine pancreas

Authored by Ignacio V. Martinez, Enrique J. Gomez, M. Elena Hernando

Date Published: 2012

DOI: 10.1504/ijdmb.2012.049293

Sponsors: No sponsors listed

Platforms: No platforms listed

Model Documentation: Other Narrative Mathematical description

Model Code URLs: Model code not found

Abstract

This paper proposes an agent-based model of the action of macrophages on the beta cells of the endocrine pancreas. The aim of this model is to simulate the processes of beta cell proliferation and apoptosis and also the process of phagocytosis of cell debris by macrophages, all of which are related to the onset of the autoimmune response in type 1 diabetes. We have used data from the scientific literature to design the model. The results show that the model obtains good approximations to real processes and could be used to shed light on some open questions concerning such processes.

Tags

Agent-based model Simulation bioinformatics autoimmune response autoimmunity innate immune system beta cell endocrine pancreas macrophage phagocytosis type 1 diabetes