A Comparison of Fully-Coupled 3D In-Stent Restenosis Simulations to In-vivo Data
Authored by Pavel S Zun, Tatiana Anikina, Andrew Svitenkov, Alfons G Hoekstra
Date Published: 2017
DOI: 10.3389/fphys.2017.00284
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Abstract
We describe our fully-coupled 3D multiscale model of in-stent
restenosis, with blood flow simulations coupled to smooth muscle cell
proliferation, and report results of numerical simulations performed
with this model. This novel model is based on several previously
reported 2D models. We study the effects of various parameters on the
process of restenosis and compare with in vivo porcine data where we
observe good qualitative agreement. We study the effects of stent
deployment depth (and related injury score), reendothelization speed,
and simulate the effect of stent width. Also we demonstrate that we are
now capable to simulate restenosis in real-sized (18 mm long, 2.8 mm
wide) vessel geometries.
Tags
Management
multiscale modelling
in-stent restenosis
Prevention
Metaanalysis
Deployment
Agent-based
modelling
Hemodynamics
Coronary vessel stenosis
Porcine coronary-arteries
Extracellular-matrix changes
Eluting stents
Blood-flow
Endothelialization
Hyperplasia