Advanced computational workflow for the multi-scale modeling of the bone metabolic processes
Authored by Tien Tuan Dao
Date Published: 2017
DOI: 10.1007/s11517-016-1572-z
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Mathematical description
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Abstract
Multi-scale modeling of the musculoskeletal system plays an essential
role in the deep understanding of complex mechanisms underlying the
biological phenomena and processes such as bone metabolic processes.
Current multi-scale models suffer from the isolation of sub-models at
each anatomical scale. The objective of this present work was to develop
a new fully integrated computational workflow for simulating bone
metabolic processes at multi-scale levels. Organ-level model employs
multi-body dynamics to estimate body boundary and loading conditions
from body kinematics. Tissue-level model uses finite element method to
estimate the tissue deformation and mechanical loading under body
loading conditions. Finally, cell-level model includes bone remodeling
mechanism through an agent-based simulation under tissue loading. A case
study on the bone remodeling process located on the human jaw was
performed and presented. The developed multi-scale model of the human
jaw was validated using the literature-based data at each anatomical
level. Simulation outcomes fall within the literature-based ranges of
values for estimated muscle force, tissue loading and cell dynamics
during bone remodeling process. This study opens perspectives for
accurately simulating bone metabolic processes using a fully integrated
computational workflow leading to a better understanding of the
musculoskeletal system function from multiple length scales as well as
to provide new informative data for clinical decision support and
industrial applications.
Tags
Simulation
Agent-based modeling
biomechanics
Multi-scale modeling
Challenges
Skeletal-muscle
Dynamic-model
Tissue
Fully integrated computational workflow
Musculoskeletal system
Rigid body modeling
Finite element modeling
Bone metabolic processes
Bone remodeling
Musculoskeletal
Homogenization
Jaw