Systematic simulation of cross-reactivity predicts ambiguity in Tk memory: It may save lives of the infected, but limits specificities vital for further responses

Authored by Yanthe E. Pearson, Yiming Cheng, Liisa K. Selin, Roberto Puzone, Franco Celada

Date Published: 2011-06

DOI: 10.3109/08916934.2011.523275

Sponsors: United States National Institutes of Health (NIH)

Platforms: No platforms listed

Model Documentation: Other Narrative Flow charts

Model Code URLs: Model code not found

Abstract

The present study uses the agent-based model IMMSIM to simulate immune responses to a viral infection, with a focus on the impact of preformed memory (homologous and heterologous) on the quality and the efficacy of the response. The in machina results confirm the observed thwarting of new, naive responses exerted by cross-reacting memory, but they also reveal that the competitive inhibition is made possible by the different time frame used by the primary and the secondary response, a well-known fact, epitomized by the interval of about 75 time steps between their peaks. This novel finding justifies the depression of naive responses and the long-term consequences it could bring about and the role of memory as a player in a survival of the fittest game.

Tags

Cross-reacting memory clonal dominance dynamic competition