Antimicrobial Stewardship and Environmental Decontamination for the Control of Clostridium difficile Transmission in Healthcare Settings
Authored by Suzanne Lenhart, Cristina Lanzas, Jason Bintz
Date Published: 2017
DOI: 10.1007/s11538-016-0224-7
Sponsors:
United States National Institutes of Health (NIH)
United States National Science Foundation (NSF)
Platforms:
No platforms listed
Model Documentation:
ODD
Model Code URLs:
Model code not found
Abstract
We implement an agent-based model for Clostridium difficile transmission
in hospitals that accounts for several processes and individual factors
including environmental and antibiotic heterogeneity in order to
evaluate the efficacy of various control measures aimed at reducing
environmental contamination and mitigating the effects of antibiotic use
on transmission. In particular, we account for local contamination
levels that contribute to the probability of colonization and we account
for both the number and type of antibiotic treatments given to patients.
Simulations illustrate the relative efficacy of several strategies for
the reduction of nosocomial colonizations and nosocomial diseases.
Tags
Agent-based model
Epidemiology
Infection
Control
Model
Clostridium difficile
disease
Impact
Risk-factors
Nosocomial transmission
Antibiotic stewardship
Asymptomatic carriers
Update