Dynamic modelling of hepatitis C virus transmission among people who inject drugs: a methodological review

Authored by A Cousien, V C Tran, S Deuffic-Burban, M Jauffret-Roustide, J-S Dhersin, Y Yazdanpanah

Date Published: 2015

DOI: 10.1111/jvh.12337

Sponsors: French Agence Nationale de Recherche sur le Sida et les Hépatites virales (ANRS)

Platforms: No platforms listed

Model Documentation: Other Narrative Flow charts

Model Code URLs: Model code not found

Abstract

Equipment sharing among people who inject drugs (PWID) is a key risk factor in infection by hepatitis C virus (HCV). Both the effectiveness and cost-effectiveness of interventions aimed at reducing HCV transmission in this population (such as opioid substitution therapy, needle exchange programmes or improved treatment) are difficult to evaluate using field surveys. Ethical issues and complicated access to the PWID population make it difficult to gather epidemiological data. In this context, mathematical modelling of HCV transmission is a useful alternative for comparing the cost and effectiveness of various interventions. Several models have been developed in the past few years. They are often based on strong hypotheses concerning the population structure. This review presents compartmental and individual-based models to underline their strengths and limits in the context of HCV infection among PWID. The final section discusses the main results of the papers.

Tags

random graphs cost-effectiveness Human-immunodeficiency-virus Hiv-infection Opiate substitution therapy Genotype 1 infection Antiviral treatment Harm reduction Hcv transmission Syringe programs