Modeling the Chagas' disease after stem cell transplantation

Authored by Viviane Galvao, Jose Garcia Vivas Miranda

Date Published: 2009-04-15

DOI: 10.1016/j.physa.2009.01.012

Sponsors: Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB)

Platforms: No platforms listed

Model Documentation: ODD

Model Code URLs: Model code not found

Abstract

A recent model for Chagas' disease after stem cell transplantation is extended for a three-dimensional multi-agent-based model. The computational model includes six different types of autonomous agents: inflammatory cell, fibrosis, cardiomyocyte, proinflammatory cytokine tumor necrosis factor-alpha, Trypanosoma cruzi, and bone marrow stem cell. Only fibrosis is fixed and the other types of agents can move randomly through the empty spaces using the three-dimensional Moore neighborhood. Bone marrow stem cells can promote apoptosis in inflammatory cells, fibrosis regression and can differentiate in cardiomyocyte. T cruzi can increase the number of inflammatory cells. Inflammatory cells and tumor necrosis factor-alpha can increase the quantity of fibrosis. Our results were compared with experimental data giving a fairly fit and they suggest that the inflammatory cells are important for the development of fibrosis. (c) 2009 Elsevier B.V. All rights reserved.

Tags

Autonomous agent computational model Cellular therapy Chronic chagasic cardiomyopathy