Hemodynamically Driven Vein Graft Remodeling: A Systems Biology Approach

Authored by Scott A. Berceli, Roger Tran-Son-Tay, Marc Garbey, Zhihua Jiang

DOI: 10.2310/6670.2008.00083

Sponsors: American Heart Association Lifeline Foundation The William J. von Liebig Foundation United States National Institutes of Health (NIH)

Platforms: No platforms listed

Model Documentation: Other Narrative Flow charts Mathematical description

Model Code URLs: Model code not found

Abstract

Despite intense investigation over several decades to understand the mechanisms of vein graft failure, few therapeutic modalities have emerged. Emphasis using standard reductionist approaches has been focused on cataloging the components involved in the early events following vein graft implantation, but limited insight has been gained in understanding the dynamic interaction of these components. We propose that the application of systems theory offers the opportunity for significant advances in this area. Focused on modeling the dynamic relationships that define living organisms, systems biology provides the necessary tools to further our understanding of the complex series of overlapping biologic events on surgical implantation of the vein graft. Through the use of ordinary differential equation and agent-based modeling techniques, we present our ongoing efforts to define the nonlinear interactions between hemodynamics and vascular adaptation.

Tags

systems biology remodeling vein graft hemodynamics