A virtual look at Epstein-Barr virus infection: Simulation mechanism

Authored by M. Shapiro, K. A. Duca, K. Lee, E. Delgado-Eckert, J. Hawkins, A. S. Jarrah, R. Laubenbacher, N. F. Polys, V. Hadinoto, D. A. Thorley-Lawson

Date Published: 2008-06-21

DOI: 10.1016/j.jtbi.2008.01.032

Sponsors: United States Public Health Service

Platforms: PathSim

Model Documentation: Other Narrative Flow charts

Model Code URLs: http://dx.doi.org/10.1016/j.jtbi.2008.01.032

Abstract

Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death. (C) 2008 Elsevier Ltd. All rights reserved.

Tags

Computer model agent based biological model human herpesvirus 6 viral persistence