Modes of evolution in a parasite-host interaction: Dis-entangling factors determining the evolution of regulated fimbriation in E. coli

Authored by Dominique Chu

Date Published: 2009-01

DOI: 10.1016/j.biosystems.2008.07.001

Sponsors: United Kingdom Engineering and Physical Sciences Research Council (EPSRC)

Platforms: No platforms listed

Model Documentation: Other Narrative

Model Code URLs: Model code not found

Abstract

Escherichia coli expresses type-I fimbriae; these are protrusions from the outer cell wall and have been identified as a virulence factor. They are also expressed by commensal strains of E. coli although (at any one time) only by a small proportion of the population, The orthodox interpretation of this is that fimbriation is regulated so as (i) to trigger a host-based release of nutrients in the form of inflammation signals by slightly activating host defenses and (ii) while avoiding a full scale inflammatory response. This article presents a number of computer simulations of the evolution of fimbriae to scrutinize the evolutionary plausibility of this orthodox view. It turns out that these Simulations Suggest a revised interpretation of the fimbriae mediated parasite-host interaction. Rather than being a passive victim the host is actively providing a niche that evolutionary favors less virulent parasites. The article closes with a number of testable predictions of this model. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

Tags

Agent-based model Evolution E. coli Fimbriation Virulence factors