Formal agent-based modelling of intracellular chemical interactions
Authored by Mike Holcombe, Rod Smallwood, Mark Pogson, Eva Qwarnstrom
Date Published: 2006-07
DOI: 10.1016/j.biosystems.2006.02.004
Sponsors:
EPSRC/BBSRC
Wellcome Trust
MRC
Platforms:
No platforms listed
Model Documentation:
Other Narrative
Mathematical description
Model Code URLs:
Model code not found
Abstract
Individual-based or agent-based models have proved useful in a variety of different biological contexts. This paper presents an agent-based model using a formal computational modelling approach to model a crucial biological system-the intracellular NF-kappa B signalling pathway. The pathway is vital to immune response regulation, and is fundamental to basic survival in a range of species. Alterations in pathway regulation underlie many diseases, including atherosclerosis and arthritis. Our modelling of individual molecules, receptors and genes provides a more comprehensive outline of regulatory network mechanisms than previously possible with equation-based approaches. The model has been validated with data obtained from single cell experimental analysis. (c) 2006 Published by Elsevier Ireland Ltd.
Tags
Agent-based modelling
chemical interaction
nuclear factor kappa B
signalling pathway