Embodied modeling approach to explore tumour cells drug resistance

Authored by Qasim Ali Chaudhry, Ayesha Sohail, Lubna Sherin, Zhiwu Li

Date Published: 2018

DOI: 10.1186/s40294-018-0055-5

Sponsors: No sponsors listed

Platforms: No platforms listed

Model Documentation: Other Narrative

Model Code URLs: Model code not found

Abstract

Mathematical modelling provides mechanistic insight of an infirmity by emulating the course of disease on individual or group level under various interventions and hence makes pragmatic contribution to complement conventional biomedical research modalities. Subsequently, real-world effectiveness is observed in the prediction of experimental outcome that leads to optimized clinical therapies. This article addresses with the aid of mathematical modelling, the drug pharmacokinetic-pharmacodynamic along with treatment responses. This article uses an agent based model to discuss the effects of chemotherapy on angiogenesis as well as tumor microenvironment and establishes pertinency between numerical and experimental results. This study supports the emerging ``discrete analysis{''} which, in the near future, is anticipated to be a promising major tool, for designing rational dosage regimes and effective dosage forms.
Tags
Migration Angiogenesis cancer Agent based modelling Drug resistance computational analysis Chemotherapy Therapy Growth-factor Angiogenic factors