Embodied modeling approach to explore tumour cells drug resistance
Authored by Qasim Ali Chaudhry, Ayesha Sohail, Lubna Sherin, Zhiwu Li
Date Published: 2018
DOI: 10.1186/s40294-018-0055-5
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Model Documentation:
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Abstract
Mathematical modelling provides mechanistic insight of an infirmity by
emulating the course of disease on individual or group level under
various interventions and hence makes pragmatic contribution to
complement conventional biomedical research modalities. Subsequently,
real-world effectiveness is observed in the prediction of experimental
outcome that leads to optimized clinical therapies. This article
addresses with the aid of mathematical modelling, the drug
pharmacokinetic-pharmacodynamic along with treatment responses. This
article uses an agent based model to discuss the effects of chemotherapy
on angiogenesis as well as tumor microenvironment and establishes
pertinency between numerical and experimental results. This study
supports the emerging ``discrete analysis{''} which, in the near future,
is anticipated to be a promising major tool, for designing rational
dosage regimes and effective dosage forms.
Tags
Migration
Angiogenesis
cancer
Agent based modelling
Drug resistance
computational analysis
Chemotherapy
Therapy
Growth-factor
Angiogenic factors