Carbon limitation drives GC content evolution of a marine bacterium in an individual-based genome-scale model
Authored by Ferdi L Hellweger, Yongjie Huang, Haiwei Luo
Date Published: 2018
DOI: 10.1038/s41396-017-0023-7
Sponsors:
Chinese National Natural Science Foundation
United States National Science Foundation (NSF)
Council of Hong Kong
Platforms:
No platforms listed
Model Documentation:
Other Narrative
Mathematical description
Model Code URLs:
Model code not found
Abstract
An important unanswered question in evolutionary genomics is the source
of considerable variation of genomic base composition (GC content) even
among organisms that share one habitat. Evolution toward GC-poor genomes
has been considered a major adaptive pathway in the oligotrophic ocean,
but GC-rich bacteria are also prevalent and highly successful in this
environment. We quantify the contribution of multiple factors to the
change of genomic GC content of Ruegeria pomeroyi DSS-3, a
representative and GC-rich member in the globally abundant Roseobacter
Glade, using an agent-based model. The model simulates 2 x 10(8) cells,
which allows random genetic drift to act in a realistic manner. Each
cell has a whole genome subject to base-substitution mutation and
recombination, which affect the carbon and nitrogen requirements of DNA
and protein pools. Nonsynonymous changes can be functionally
deleterious. Together, these factors affect the growth and fitness.
Simulations show that experimentally determined mutation bias toward GC
is not sufficient to build the GC-rich genome of DSS-3. While nitrogen
availability has been repeatedly hypothesized to drive the evolution of
GC content in marine bacterioplankton, our model instead predicts that
DSS-3 and its ancestors have been evolving in environments primarily
limited by carbon.
Tags
Populations
Mutations
Ocean
Biogeographic patterns
Lakes
Prochlorococcus
Likelihood
Lineages
Clade